These cutting-edge nano technologies are only a sampling of what you’ll find in the May issue of Nanotech Briefs:

Moving Electrons at the Molecular and Nanometer Scales

Researchers at Brookhaven National Laboratories are trying to develop models to understand the interactions in molecular systems, where complex molecules with arbitrary shapes communicate electronically over long distances. Learning how to control the movement of electrons on the molecular and nanometer scales could help scientists devise small-scale circuits for a wide variety of applications, including more efficient ways of storing and using solar energy.

Sampling Small Atmospheres in MEMS Devices

Researchers at Sandia National Laboratories have developed an advanced sampling procedure that requires only picoliters of gas to evaluate the contents of the small atmospheres of MEMS devices. The method involves a small commercial valve that comes down like a trash compactor and crushes a tiny device until it releases its gases - currently, about 30 nanoliters - into a custom-built intake manifold. The researchers hope to be able to measure the quality of vacuums.

Nanoscale Memory for Silicon Chips

Scientists at Philips Research have developed an innovative phase-change memory that promises to match the speed, density, low-voltage, and low-power consumption requirements of future, deep sub-micron silicon chips. The new solid-state memory cell employs similar phase-change materials deposited as an ultra-thin film on the surface of a silicon chip, and uses an electric current to switch it between phases and to detect the resultant change in its electrical resistance. Philips’ new “line-cell” phase-change memory has the potential to meet both the performance and scaling requirements of future nanoelectronic silicon chips.

Self-Assembling Nanostructures Provide Insight Into Radioactivity

Discovered by researchers from Argonne National Laboratory and the University of Notre Dame, a new class of materials could enhance basic understanding of how radioactive materials behave in the environment. Called actinyl peroxide compounds, these materials self-assemble into nano-sized, hollow cages that could have useful new electronic, magnetic, and structural properties important to the emerging world of nanotechnology.

Global bio-nanotech company pSivida Limited (NASDAQ:PSDV)(ASX:PSD)(Xetra:PSI) today announced that pSivida CEO, Mr. Gavin Rezos, will present on Day One of the NanoEquity Europe 2006 Conference to be held today and tomorrow in Frankfurt. Mr. Rezos will update the market on the Company’s progress at a forum that is focused on the European capital market and equity acquisition for companies in the areas of micro and nano technologies.

The NanoEquity Europe 2006 Conference is organized and promoted by the Frankfurt Stock Exchange. More than 400 participants of the German and European financial community are expected to take part each day of the conference representing listed and non listed nanotech / micro-nanotech companies, institutional investors, fund managers, asset managers, private equity investors, scientists, and nanotech experts.

This document contains forward-looking statements that involve risks and uncertainties. The statements reference potential products, applications and regulatory approvals. Although we believe that the expectations reflected in such forward-looking statements are reasonable at this time, we can give no assurance that such expectations will prove to be correct. Given these uncertainties, readers are cautioned not to place undue reliance on such forward-looking statements. Actual results could differ materially from those anticipated in these forward-looking statements due to many important factors including: our inability to develop proposed products, including without limitation, in the drug delivery, wound healing, orthopaedics, and tissue engineering, diagnostics and food technology fields; failure of our evaluation agreements to result in license agreements; failure to develop applications for BioSilicon(TM) due to regulatory, scientific or other issues;failure to complete negotiations for new centers for the BrachySil(TM) phase IIb clinical trial for inoperable primary liver cancer; failure of our discussions with the FDA for BrachySil(TM) to continue or to lead to FDA approval; failure of the BrachySil(TM) phase IIb clinical trial for inoperable primary liver cancer to determine the optimal dose, provide key safety data or support future pivotal efficacy trials or product registration or approval; failure of the BrachySil(TM) primary liver programme that is in phase IIb clinical trials to provide a valuable platform for the development and commercialization of BrachySil(TM) for pancreatic cancer and other indications; failure to commence phase IIa BrachySil(TM) trials for the treatment of pancreatic cancer; failure of the findings of the pancreatic cancer phase IIa trial to provide a platform for further multicenter efficacy and safety trials; failure of there to be optimization and standardization between our two pancreatic cancer study centers; failure of the results of the Retisert(TM) for DME trial to be a good indicator of the results of pSivida’s ongoing phase III Medidur(TM) for DME trial; failure of the Medidur(TM) trials in DME to show a very similar improvement in visual acuity and diabetic retinopathy severity score as Retisert(TM) for DME; failure of Medidur(TM) to release fluocinolone acetonide at the same rate as Retisert(TM); our inability to recruit patients for the phase III Medidur(TM) for DME trial;. Other reasons are contained in cautionary statements in the Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission, including, without limitation, under Item 3.D, “Risk Factors” therein. We do not undertake to update any oral or written forward-looking statements that may be made by or on behalf of pSivida.

Leveraging a well-hyped but still-emerging science, two Johns Hopkins University engineers have launched a company that uses special equipment to manipulate material a few atoms at a time.

The commercial applications of this kind of science, called nanotechnology, are vast, yet also highly speculative. Investors are excited about the possibilities of creating materials that today are only pipe dreams, with some wondering whether nanotech could drive the next boom in high-tech spending and innovation, but they are moving forward cautiously.

In the case of Reactive NanoTechnologies, the founders say they have discovered a way to create a metal foil that can be heated to 1,500 degrees centigrade, using nothing more than a nine-volt battery as a power source. Only the foil, and anything touching it, would be heated via this process.

Why would anyone want to do such a thing? Because the foil — which is nothing more than a thin metal disk of nickel and aluminum, demonstration models of which are not much bigger than a coin — can be inserted between materials that manufacturers want to fuse together, serving as a kind of welding agent when the foil is heated.

“You could call it atomic science because we’re working with nanometers — an atom is about two-tenths to three-tenths of a nanometer,” said Timothy P. Weihs, the CEO, president and co-founder of Reactive NanoTechnologies. “I’d call this almost atomic engineering.”

But for Reactive, this is no mere science experiment.

A decade in the making, the company is now preparing to move out of its “virtual” office at Baltimore’s Emerging Technology Center incubator (as a practical matter, its real office is at Hopkins’ Homewood campus), and into permanent space. It has landed several beta clients. And it is finalizing its first round of venture capital investment, a $2 million infusion led by Toucan Capital Corp.

Weihs and his co-founder, Omar Knio, decline to name their clients, but their initial targets include the military and electronics makers. Both have an interest in Reactive’s high- temperature foils because they solve a problem that arises in attempting to fuse ceramic and metal materials.

The laws of physical science demand that ceramic and metal expand when they’re heated and contract when they cool. The problem is that metal does both of these to a larger extent, making it difficult to weld the two together.

“We overcome that because we don’t heat the elements — we just heat the foil,” says Weihs.

The foil is inserted between the two elements to be fused, along with solder, easily melting the materials together without melting anything else. A cell phone manufacturer could fuse the metal and ceramic components of its product by putting both in a furnace, but the result would be a liquefied phone.

Robert F. Hepfield, a managing director of Toucan Capital in Bethesda, said venture capitalists are interested in such technology for two reasons: First, the science has reached the stage where viable commercial applications are beginning to come into focus, and second, because those applications are plentiful. Since nanotechnology allows for the creation of new types of previously unproduceable materials, the possible applications are limited only by the imagination.

“The more [scientists] learn, the more they expect nanoscience and nanoengineering will become as socially transforming as the development of running water, electricity, antibiotics and microelectronics,” intones the National Science Foundation’s National Nanotechnology Initiative, in a recent report. The NNI asks: “What if we could build things the way nature does: atom by atom, molecule by molecule?”

What if, indeed. But it isn’t the mere ability to manipulate atoms that interests the investment world, according to Hepfield.

“When you strike a match, you’re manipulating material at an atomic level,” he said. “It’s the ability to control that that’s really exciting here.”

Still, he cautions against getting too excited.

“We’ve looked at probably 20 business plans that say they work with nanotechnology, and only one or two are even close,” he said. “There’s a lot more hype than reality, but that’s OK. That’s how it always starts.”

He declined to talk about Reactive because the venture fund’s investment in the startup is not yet final. But it’s fair to say that if anything, the reality of the company appears to outstrip the hype for a change, since Reactive, with its glorified soldering iron, is currently exploiting only a sliver of the possible nanotechnology universe.

Yet it’s a promising sliver. The military wants to fuse its new ceramic armor to its old metal tanks, but that’s a problem Reactive may be able to solve. Makers of electronic gadgets, such as cell phones and personal digital assistants, use adhesives, not ovens, to fuse the metal and non-metal components of their machines, but that’s limiting.

“For now, it works,” said Knio, Reactive’s vice president of research and development. “But as processors shrink … this glue has been the limitation [to miniaturization]. It works, but it’s becoming more and more of a disadvantage.”

VESTA’s VULCAN(TM) Metal ALD/VPD System can provide in-situ and/or sequential dual mode of ALD with VPD processing capability. VESTA’s dual mode deposition technology integrates a precision ALD for initial layers with high throughput from various type of deposition obtained from gas phase of chemicals such as pseudo-ALD, pseudo-CVD, CVD, etc for bulk layers. Both the initial ALD layer and the VPD fill are deposited within the same VULCAN(TM) Process Module with or without plasma option.

The integration of in-situ and/or sequential deposition approach overcomes both the film quality limitation of CVD processing and the low deposition rate limitation of ALD processing. By adopting plasma technology, low temperature deposition is achieved for gate electrodes, back-end-of the line (BEOL) applications, and applications utilizing polymeric substrates.

“We are pleased with the latest addition to our ALD System product portfolio. Evolution of our core technology further strengthens and broadens our complete offering of Atomic Layer Deposition Process solutions,” said Chuck Kim, executive director of VESTA Technology. “Through partnership with ATDF (Advanced Technology Development Facility), an independent subsidiary of SEMATECH Inc., our advanced R&D and Customer Demonstration facility enables VESTA Technology to continue to provide our customers with innovative and leading-edge technology solutions to address today’s semiconductor device manufacturing challenges. Our complete ALD portfolio further positions VESTA Technology as a leading global supplier in our industry.”

With the evolution of VESTA’s ALD System, VESTA can provide complete ALD technology solution with technical flexibility of single wafer processing and the versatility of plasma capability for production requirement. VESTA’s ALD System’s success is due to its ability to offer revolutionary technology and proven production reliability with progressed developments for improved productivity performance.

For more information please visit us at our Booth #5486 (North Hall) SEMICON West 2005 — San Francisco, or visit our website at www.vestatechnology.com.

About VESTA Technology, Inc.: VESTA, headquartered in San Jose, Calif. is a leading supplier of next generation thermal processing and deposition solutions to the global semiconductor and nano-technology industries. VESTA’s R&D and Demo facilities are located in Austin, Texas. IPS Ltd., located in Pyungtaek, S. Korea is an exclusive partner and equipment provider to VESTA with an exclusive technology license and world-wide distributorship agreement.

These cutting-edge nano technologies are only a sampling of what you’ll find in the July issue of Nanotech Briefs:

Nanotubes Hold Promise for Fuel Cells

Scientists at the National Institute of Standards and Technology demonstrated that titanium atoms can attach above the centers of single-walled carbon nanotubes. The quantum calculations and modeling conducted by the researchers revealed that each titanium atom can bond with four hydrogen molecules, a key capability to long-term efforts to develop fuel cells for future automobiles.

Nanoscale Photonic Technology

Scientists at Lawrence Berkeley National Laboratory and the University of California at Berkeley, working with free-standing, chemically synthesized nanowires and nanoribbons, have been able to guide pulses of laser light through a variety of complex structures. The researchers have demonstrated that these nanosized ribbons can serve as “waveguides” for channeling and directing the movement of light waves through circuitry.

Technique May Speed DNA Analysis

A “nano-printing” technique developed at MIT could enable the mass production of nano devices currently built one at a time. The most immediate candidate for this innovation is the DNA microarray, a nano device used to diagnose and understand genetic illnesses such as Alzheimer’s, viral illnesses such as AIDS, and certain types of cancer. In the new method, called Supramolecular Nano-Stamping (SuNS), single strands of DNA essentially self-assemble upon a surface to duplicate a nanoscale pattern made of their complementary DNA strands.

Single-Molecule Transistor Regulates Conductivity

A team of researchers from the National Institute for Nanotechnology of the National Research Council and University of Alberta, Canada, have designed and tested a new concept for a single-molecule transistor. They demonstrated that a single atom on a silicon surface could be controllably charged, while all surrounding atoms remain neutral. A molecule placed adjacent to that charged site is “tuned,” which allows electrical current to flow through the molecule from one electrode to another.

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Reserve your place at NANO 2005 - The Nano Engineering Conference & Expo

November 10-11, 2005 * Boston Marriott Newton

www.techbriefs.com/nano

Featuring the Nano 50(TM) Awards - the top technologies, products, and innovators transforming the commercial market

The results are in for the first annual Nano 50(TM) awards competition! Recognizing the top 50 technologies, innovators, and products with the greatest potential to advance the commercialization of nanotechnology, the Nano 50 award winners will be honored at a special awards dinner to be held during NASA Tech Briefs’ NANO 2005 conference in Boston.

The NANO 2005 conference will present the latest information on commercial applications utilizing nanotechnology, as well the latest technologies from engineers designing tomorrow’s nanotech products today.

It’s hard to pinpoint exactly what small tech is because it has so many wide-ranging applications. “I would call it more of a revolution than an evolution,” says Snyder. Nanotechnology, for example, deals with matter at an atomic and molecular level–that is, with matter often described as being less than the width of a human hair in size. It’s appearing in everything from stainproof coating for fabrics to scratch-resistant coating for eyeglasses to miniscule computer chip circuits from HP Labs.

Research funding for small tech is enormous. Ardesta is devoted to investing in and helping launch various small tech ventures with an ultimate goal of bringing actual products to market. Many businesses in this fledgling technological area are small entrepreneurial start-ups and spin-offs from research institutions. Life sciences and materials manufacturing are two industries that will really feel the early effects of the growing small tech market.
Eventually, though, small tech will touch just about everything. Synder calls it pervasive and transparent. Some applications are out already and operating in your business right under your nose. Microtech is built into inkjet cartridges and portable projectors. At SmallTimes.com, a clearinghouse for information on small technology, the section devoted to applications is an eye-opener: A recent visit to the site brought up articles on nanotech use in products such as tennis rackets and LCD monitors, among others.

There are a million microscopic reasons to get excited, but it’s important to keep them all in perspective. Synder sees an accelerating growth curve over the next five years as small tech makes its way into real-life markets. But you shouldn’t expect companies to shout “nano” or “MEMS” in their product advertising. The way you’ll know small tech has touched your business is when Snyder’s mantra comes into play: “Smaller, faster, better, cheaper.”

The new development enables Mazda to reduce the amount of platinum and palladium used in automotive catalysts by 70 to 90 percent. It does not result in any changes in the performance of purifying gas emissions and maintains the high durability of conventional catalysts. Single-nanotechnology is a technology that can control even smaller particles than nanotechnology.

In automotive catalysts, precious metals promote chemical reactions that purify exhaust gases on their surfaces. In conventional catalysts, the precious metals are adhered to a base material. Exposure to exhaust gas heat causes the precious metal to agglomerate into larger particles. This reduces the catalyst’s effective surface area and catalytic activity, which requires the use of a significant amount of precious metals to counter and maintain an efficient purification performance.

In order to increase the precious metal surface area, Mazda developed a new catalyst using its proprietary catalyst material structure and precious metal particles that are less than 5 nanometers (nm) in diameter. This is the first time that a catalyst material has been achieved that features single, nanosized precious metal particles embedded in fixed positions.
As a result, there is no agglomeration of the precious metal particles, and the amount of high-priced precious metals used in three-way catalytic converters - which purify gasoline-engine exhaust gases - can be reduced by 70 to 90 percent. Moreover, the new catalyst material will maintain the same level of purifying efficiency, with minimal deterioration over time even under the harshest operating conditions.

About Mazda Motor Corporation

Mazda Motor Corporation (TSE: 7261) started manufacturing tools in 1929 and soon branched out into production of trucks for commercial use. In the early 1960s, Mazda launched its first passenger car models and began developing rotary engines. Still headquartered in Hiroshima in western Japan, Mazda today ranks as one of Japan’s leading automakers, and exports cars to the United States and Europe for over 30 years. Overseas sales account for more than half of total turnover. Mazda has two main production sites in Japan and 19 overseas facilities. Overseas sites include joint ventures based in the United States, and in Thailand with Ford Motor Company, Mazda’s largest shareholder.

The 17 papers contained in this volume review recent advances in nanotechnology in the field of medical therapeutics. Peppas (chemical and biomedical engineering, U. of Texas at Austin), Hilt (chemical and materials engineering, U. of Kentucky), and Thomas (chemical engineering, U. of Texas at Austin) have organized the contributions into sections covering “intelligent therapeutics,” which involves responsive devices and drug delivery systems that can detect and respond to biological undesirables and/or release drugs, proteins, or therapeutic agents; therapeutic micro- and nanodevices; nanostructured therapeutic materials; and nanoparticulate systems in intelligent therapy, although there is often significant thematic overlap. Examples of specific topics addressed include nanoscale analysis of mucus-carrier interactions for improved drug absorption, polymeric gene delivery vectors, scientific and engineering approaches to biomimetic systems, nanostructured scaffolds for tissue engineering, star polymers and dendrimers in nanotechnology and drug delivery, and nanoparticulate structures in diabetes treatment. Distributed in the US by Taylor & Francis.

Hardcover

T174

With the hundred of millions the US government has budgeted for research and development in mind, other nations expect nanotechnology to be a significant player in creating technology, generating market growth, and making advances in national security. In this collection, articles describe the research and applications being developed in China (including private development), Korea (including research into carbon nanotubes), Europe (including a listing of funding policies by nation) and the US (including preparation of a diverse nanotechnology workforce). Other articles cover such topics as methods of investing in nanotechnology, and new technologies and applications, such as polymeric nanofibers, textiles, and measurement standards.

In this collection experts examine recent research in three subfields: nanodrugs and drug delivery; prostheses and implants; and diagnostics and screening technologies. The contributors compare new capabilities introduced by nanotechnology to traditional methods of release, target and controlled drug delivery in the body. They also consider the challenge of understanding and controlling the biological processes involved upon implantation and discuss nanoscale sensors for biological chemical detection and biodefense. The text concludes with chapters devoted to the social and economic context of nanotechnologies and to their potential risks and possible solutions for those risks.

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